Genetic Correlation Between Schizophrenia and Epilepsy.

Genetic Correlation Between Schizophrenia and Epilepsy Neuropathological, clinical, and epidemiological data suggest that schizophrenia and epilepsy are associated.1 Reported estimates of the prevalence of schizophrenia among people with epilepsy vary, depending on phenotypic definition, but may be around 7%.2 One hypothesis to account for the relationship is that the 2 diseases share a common etiology.Methodological advancesnowmake it possible to test the extent towhichgeneticpredisposition is commonto the2conditions based onmolecular genetic data.3 We sought to do so using publically available genome-wide association study (GWAS) summary statistics from large meta-analyses of schizophrenia4 and epilepsy.5 In this retrospective casecontrol analysis, we used a technique called linkage disequilibrium(LD) score regression (knownasLDSCregression) to estimate the genetic correlation (rG) between these common disorders.3